5th International Conference on Gynecology and Obstetrics

Baizhanova Aliya Nagymetqyzy is a resident physician in Obstetrics and Gynecology at Asfendiyarov Kazakh National Medical University, Kazakhstan. Her scientific interests include women’s reproductive health, cervical cancer prevention, high-risk human papillomavirus (hrHPV) infection, cervical intraepithelial neoplasia, and vaginal microbiota. Her research focuses on understanding the persistence of high-risk HPV infection and the role of microbiological and systemic factors in the development and progression of cervical lesions. She is actively engaged in clinical training and scientific research in obstetrics and gynecology, with a particular interest in evidence-based approaches to the prevention and early detection of cervical precancerous conditions.

Background: Persistent infection with high-risk human papillomavirus (hrHPV) is the major etiological factor in the development of cervical intraepithelial neoplasia (CIN). However, the progression of cervical lesions is influenced by a combination of reproductive, microbiological, and immunological factors.

Objectives: To assess the relationship between persistent hrHPV infection and the severity of cervical intraepithelial neoplasia, with particular attention to reproductive, microbiological, and systemic factors.

Methods: A clinical and laboratory study was conducted among 163 women of reproductive age with histologically confirmed cervical intraepithelial neoplasia. Patients were classified according to the severity of cervical lesions. HPV genotyping, assessment of vaginal microbiota, and evaluation of selected clinical and laboratory parameters were performed. Associations between hrHPV persistence, HPV 16/18 infection, vaginal dysbiosis, and CIN severity were analyzed.

Results: HPV 16 and/or 18 were detected in 49.1% of the examined patients. Their prevalence increased with the severity of cervical lesions, reaching 64% among patients with high-grade lesions. Vaginal dysbiosis was identified in 55.8% of women. Reduced ferritin levels were observed in 31.9% of patients, anemia in 28.2%, and vitamin D deficiency in 54.6%. The findings demonstrated an association between persistent hrHPV infection and the severity of cervical epithelial lesions, with concomitant microbiological and systemic factors potentially contributing to disease progression.

Conclusion: Persistent hrHPV infection, particularly HPV 16/18, is strongly associated with the development and severity of cervical intraepithelial neoplasia. Vaginal dysbiosis and selected systemic factors may contribute to HPV persistence and progression of cervical lesions. Comprehensive assessment of these factors may improve risk stratification and individualized management of women with hrHPV infection.