Ranitya Indra Amdhani Rauf
Hasanuddin University, IndonesiaTitle: Correlation between resistin in obese adolescents
Abstract
Background: Obesity has a significant impact on female
fertility due to functional changes to the HPO axis. Obesity is often
associated with higher circulating insulin levels which will then increase
ovarian androgen production. These changes will eventually result in ovulatory
dysfunction and menstrual cycle abnormalities. Serum resistin have been
associated with increased insulin resistance and in the development of type 2
diabetes mellitus. Increased insulin resistance by elevated serum resistin levels
is associated with exacerbation of PCOS symptoms.
Objectives: This study aimed to evaluate the relationship
between serum resistin with menstrual disorders and signs of hyperandrogenism
in obese adolescents.
Methods: This study used a cross-sectional design that
compared serum resistin levels between obese adolescent girls with and without
menstrual disorders group and between obese adolescent girls with and without
hyperandrogenism signs.
Results: Serum resistin levels in the group of obese
adolescents with oligomenorrhea and obese adolescents without oligomenorrhea
were not statistically significant (1401.4 ± 855.9 vs 1117.11 ± 815.7,
p=0.163). The correlation between serum resistin levels in obese adolescents
was found to be very weakly associated and not statistically significant.
Conclusion: Increased serum resistin have no correlation to
menstrual cycle disorders and hyperandrogen signs in obese adolescents.
Biography
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