Farah Naz Mabud

Chattogram Maa O Shishu Hospital Medical College, Bangladesh

Title: Oral nifedipine versus intravenous labetalol in the management of severe pregnancy induced hypertension: A randomized control trial

Abstract

The objective of this study is to assess the efficacy of oral Nifedipine and I/V Labetalol for lowering BP in severe PIH after 28 weeks of pregnancy. In this study 100 subjects were selected with severe pregnancy induced hypertension who were randomly allocated into two groups, A & B. Group A received initially tablet nifedipine 10 mg orally with repeated doses of 20 mg every 20 minutes upto five doses while Group B received intravenous labetalol 20 mg initially followed by escalating doses of 40, 80, 80 and 80 mg every 20 minutes until the therapeutic goal blood pressure Systolic < 150 mmHg & diastolic < 100 mmHg was achieved. Primary outcomes were the time interval and the number of doses needed to achieve a blood pressure of < 150/100 mmHg, Secondary outcomes were fetomaternal safety, efficacy and side effects of both drugs. Proportion of target BP achievement were 100% in Group A and it was 72% in Group B(P<0.05). Need of drug dose and time of reduction was found significantly less among Group A women (P<0.05). Change of mean ± SD, SBP was more rapid in Group A ( 174.90 ± 20.01 vs 158.40 ± 11.13) women than Group B ( 179.80 ± 16.54 vs 167.40 ± 15.02) after first dose. It was same for DBP also. Need of mean dose were less in group A than Group B (1.72 vs 3.30) also total time needed to achieve target BP was less in Group A (34.40 vs 66.0 mins). Side effects of drugs were found more in Group B (8% vs 4%) and fetal death also more common in there (8% vs 16%). Nifidipine lowers blood pressure more rapidly with fewer doses with minimum fetomaternal side- effects.

Biography

Farah Naz Mabud has completed her MS in Obs & Gynae from University of Chittagong, Bangladesh. She has done her advanced training in ART from Bangalore, India. She has completed her different trainings on Colposcopy, Laparoscopy and Hysteroscopy. She has 7 publications in National and International Journals. She has presented in RCOG, UK and SAFOG conference. College. She has special interest on Infertility. Besides, she has teaching experience of 19 years in different Medical Colleges. Currently she has been working as Assistant Professor at Chattogram Maa O Shishu Hospital Medical

2nd International Conference on Gynecology and Obstetrics

Farah Naz Mabud

Title: Oral nifedipine versus intravenous labetalol in the management of severe pregnancy induced hypertension: A randomized control trial

Abstract

Biography

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