Asaad MA Babker
Gulf Medical University, UAETitle: Detection of human platelets antigen polymorphism (HPA-1 and HPA-3) and human factor XIII mutation in Sudanese women with recurrent pregnancy loss
Abstract
Recurrent pregnancy Loss (RPL) is a common problem affecting many couples. Certain genetic variants link to increase the danger of this condition particularly HPA-1, HPA-3, and Human Factor XIII Val34Leu Mutation. Rrecurrent pregnancy loss (RPL) is a complex phenomenon characterized by two or more recurrent pregnancy miscarriages prior to the 20th week. It has emerged as a reproductive health concern affecting 1%–5% of pregnant women. Recurrent miscarriage can have multiple etiologies, including endocrine, chromosomal, anatomical, genetic, and hereditary causes. Among the environmental causes, lead and ethylene oxide exposure are implicated to be potential causes of recurrent miscarriage. Additionally, RPL may result due to immune system dysfunction and coagulation factor mutations. Despite extensive investigations, approximately 40% to 50% of cases remain idiopathic. Homeostasis is the physiological process that stops bleeding in damaged blood vessels. This process involves a series of interconnected steps that culminate in the formation of a "plug" that seals off the injured area. The first step in hemostasis is the constriction of the damaged blood vessel followed by the transient formation of a "platelet plug" which leads to activation of coagulation pathway, leading to the final clot or "fibrin plug" formation. Factor XIII, also known as fibrin-stabilizing factor, plays a crucial role in stabilizing blood clots during the coagulation cascade. It is a plasma protein heterodimer composed of A and B subunits, which are expressed by bone marrow and mesenchymal lineage cells. Factor XIII is a transglutaminase enzyme, catalyzing cross-linkage peptide reactions that contribute to the stability and strength of the fibrin clot. Gene polymorphism in thrombophilia genes had been implicated with the risk of RPL. The human platelet antigen (HPA) system consists of over 12 biallelic antigen polymorphisms, with HPA-1 and HPA-3 being potential causes of neonatal alloimmune thrombocytopenia, post-transfusion purpura, and platelet refractoriness
Biography
Asaad MA Babker joined Gulf Medical University in Febraury 2017 with more than 15 years of teaching and research experience in the area of Medical Laboratory Science with different academic positions in Sudan, Saudi Arabia and Jordan. He has more than 60 publications (articles, chapters and books) in internationally recognized journals and publishers.
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