Alyaa Sajid Mohammed Ali
Kamal AL-Sammaraiee Fertility Hospital, IraqTitle: Correlation between resistin and follistatin hormones with pregnancy outcome in samples of Iraqi women undergoing ICSI cycle
Abstract
Resistin and follistatin levels have been found to be high in Polycystic Ovarian Syndrome (PCOS) patients, indicating that the adipokines may have a role in pathophysiology of PCOS and pregnancy in women having ICSI cycle. The aim of study: Determining the relationship between resistin and follistatin hormone levels with pregnancy outcome in PCOS and non-PCOS women undergoing intra-cytoplasmic sperm injection (ICSI) program. The study was carried out at Higher Institute for Infertility Diagnosis and Assisted Reproductive Technologies from November 2022 to April 2023. Eighty infertile women participating in the IVF/ICSI treatment. They were split to control (non-polycystic ovarian syndrome- PCOS-) group (40 women) and 40 women for PCOS group. The groups were subdivide to subgroups’ according to body max index (BMI ;normal and overweight / obese). ELISA method was used to measure resistin and follistatin level at day 2 and follicular fluid and serum at day of Ova Pick Up (OPU). About 38.8% of study participants were got pregnant. Means of serum resistin and follistatin in day 2 and OPU were significantly higher in patients with PCOS and normal BMI level while follistatin at day 2 and in follicular fluid were significantly higher in participants who got pregnant. Follistatin level at day 2 was > 9.89 pg/ml and in follicular fluid was> 15.06 pg/ml are predictors for occurrence of pregnancy after ICSI. As conclusion, Resistin and pregnancy rate did not correlate with pregnancy. However, the cutoff point of follistatin level in the serum at day two and in FF at the day OPU was found to be a predictor of pregnancy following ICSI. Resistin and follistatin may be helpful indicators in the emergence of PCOS.
Biography
Alyaa Sajid Mohammed Ali completed her medical degree in 2004, earned her first diploma degree in gynaecology in 2014 in Sulaimanyi and finished her diploma in infertility in 2023 in Baghdad, I worked in various Iraqi hospitals, government and within the private sector, in my field of specialization. I also had a specialized course in gynecological laser for the year 2016. She had many surgical achievements in her field of obstetrics and gynecology then in the infertility field had many successful pregnancy rates as in IVF or IUI.
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