Pornpawee Wangsatidtongbai
Prince of Songkla University, ThailandPresentation Title:
A retrospective comparative study on the relationship between Grade 2 or higher leukopenia and survival outcome in recurrent cervical cancer patients undergoing systemic chemotherapy
Abstract
Leukopenia is the most common hematologic toxicity associated with systemic chemotherapy. However, its prognostic significance in patients with recurrent cervical cancer remains unclear. This study aimed to evaluate the association between grade 2 or higher leukopenia and 3-year survival outcomes in patients with recurrent cervical cancer receiving systemic chemotherapy.
Methods: This retrospective analysis included patients with recurrent cervical cancer who received at least three cycles of systemic chemotherapy at Songklanagarind Hospital between January 2000 and June 2022. Complete blood counts obtained prior to each chemotherapy cycle were reviewed. Patients were classified into two groups: those who developed grade ≥2 leukopenia (<3,000/μL according to the WHO toxicity classification) and those without leukopenia of any grade. Three-year survival rates were assessed using Kaplan-Meier survival analysis and Cox proportional hazards modeling.
Results: A total of 164 patients with recurrent cervical cancer were included. Eighty percent had locally advanced disease at initial diagnosis. The mean age was 52.4 ± 11 years, and more than half received platinum-based chemotherapy. Twenty-nine patients developed grade ≥2 leukopenia between the first and third cycles of systemic chemotherapy. The median 3-year survival was 29 months in the leukopenia group compared with 18.3 months in the non-leukopenia group. The 3-year survival probabilities were 0.40 and 0.19, respectively (95% CI, p < 0.05). Multivariate analysis confirmed that grade ≥2 leukopenia was independently associated with improved survival outcomes (hazard ratio [HR] = 0.55, 95% CI: 0.32–0.95, p < 0.05).
Conclusion: Leukopenia during chemotherapy was associated with improved survival outcomes in patients with recurrent cervical cancer. These findings suggest that chemotherapy-induced leukopenia, in the absence of febrile neutropenia, may serve as a potential marker of treatment efficacy in this patient population.
Biography
Pornpawee Wangsatidtongbai, MD, is a second-year Fellow in Gynecologic Oncology at Prince of Songkla University. She earned her medical degree from Princess of Narathiwat University and completed her residency in Obstetrics and Gynecology at Bhumibol Adulyadej Hospital. Her research interests focus on improving the quality of life and access to care for women with cancer in the three southern border provinces of Thailand.
Organization Location
1309 Coffeen Avenue, STE 1200, Sheridan, Wyoming 82801, USA
Mail us at
Program Enquiry
gynaecology@scientexconferences.com
General Enquiry
contact@scientexconferences.com
Registration query
finance@scientexconferences.com
gynaecology@scientexevents.org
Our Social Presence
Call us at
USA : (+1) 510 370 1954