Introduction: Diagnosing a brain tumor is challenging for any patient. However, it is even more challenging for pregnant women. The unique physiological state of pregnancy poses challenges and affects the timing of treatment 1. The lack of information regarding the care of pregnant patients diagnosed with brain tumors and the management of this group of patients poses diagnostic and therapeutic challenges.

Clinical case: The following case involves a 37-year-old secundigravid woman who is 13.5 weeks pregnant and presenting with an intense and persistent headache. Magnetic resonance imaging was performed, revealing a right postcentral and temporal intra-axial tumor with malignant characteristics and midline deviation. She underwent an emergency craniotomy, with the definitive biopsy result indicating grade IV glioblastoma, making her not a candidate for cytoreductive treatment. The pregnancy continued to progress normally until its resolution at 35.6 weeks due to vaginal bleeding secondary to placenta accreta. After delivery, palliative treatment with chemotherapy (temozolomide), 10 sessions of radiotherapy, and an anticonvulsant (levetiracetam) were initiated. At the last follow-up appointment, two years and four months later, she continued the same palliative treatment.

Conclusion: Glioblastomas are extremely rare during pregnancy. Its biological behavior during pregnancy has been little studied due to its low incidence and prevalence in pregnant women. In this case, the glioblastoma did not alter the course of the pregnancy; however, early diagnosis was critical to prevent maternal death secondary to pontine herniation.

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