Alvin Setiawan
Padjadjaran University, IndonesiaPresentation Title:
Chitinase-3-like protein 1, matrix metalloproteinase-9, and monocyte chemoattractant protein-1 as potential biomarkers and treatment targets of adenomyosis
Abstract
Study aimed to investigate the levels of chitinase-3-like protein-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9), and monocyte chemoattractant protein-1 (MCP-1) in adenomyosis, as compared to normal myometrial tissue. This was a correlative, analytical, and observational study with a cross-sectional design. Participants with a diagnosis of moderate-to-severe adenomyosis, as determined through transvaginal ultrasonography and histological examination, and who underwent laparotomy or laparoscopic surgery for the treatment of adenomyosis, were enrolled in the study. Unlike other studies that recruited healthy women as controls, our study used adenomyotic and healthy non-adenomyotic myometrium obtained from the same individual. The levels of CHI3L1, MMP-9, and MCP-1 in the biopsy samples were determined using enzyme-linked immunoassay kits, according to the manufacturer’s protocol. This study found a highly significant increase in the levels of CHI3L1, MMP-9, and MCP-1 in adenomyotic tissues compared to non-adenomyotic tissues (P<0.001). A significant positive correlation was found between CHI3L1 and MMP-9 levels (r=0.463; P=0.008), CHI3L1 and MCP-1 levels (r=0.594; P<0.001), and MCP-1 and MMP-9 levels (r=0.680; P<0.001) in adenomyotic tissues. CHI3L1 may play a role in the pathogenesis of adenomyosis via the regulation of the MCP-1 and MMP-9 pathways. Therefore, these molecules may serve as biomarkers and potential therapeutic targets for adenomyosis.
Biography
Alvin Setiawan completed his medical education in 2005 from Gajah Mada University, Yogyakarta, Indonesia. He continued his residency program in obstetrics and gynecology as well as became a trainee in reproductive endocrinology and infertility at Dr. Hasan Sadikin Central Public Hospital / Padjadjaran University, Bandung, Indonesia. Currently, he lives in Jakarta, Indonesia and serves as head of the OB/GYN Department at MRCCC Siloam Hospital Semanggi and is also a staff member of the OB/GYN Department at Dr. Mintoharjo Naval Hospital and Abdi Waluyo Hospital. He has several national and international publications.
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